Transcranial Direct Current Stimulation of the Leg Motor Area - is it partly somatosensory?

Non-invasive brain stimulation such as transcranial direct current stimulation (tDCS) involves passing low currents through the brain and is a promising tool for the modulation of cortical excitability. We computationally investigated the effects of the size of the anode in the conventional montage (contralateral supraorbital cathode) using finite element analysis (FEA) for the targeted leg area of the motor cortex where tDCS is challenging due to the depth and orientation of the leg motor area in the inter-hemispheric fissure. We used FEA to develop two anode sizes (same cathode size) with the same current density but different electric field magnitude at the targeted leg area of the motor cortex. Then, we evaluated the effects of the two anode sizes via neurophysiological testing on twelve healthy subjects, seven males and five females (age: 21-36 years, all right-leg dominant). Here, conventional anodal tDCS electrode montage for the leg area of the motor cortex used a large-anode (5cmx7cm, current strength 2mA) which was compared based on transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEP) with a small-anode (3.5cmx1cm at 0.2mA) montage of the same current density at the skin-electrode interface and identical contralateral supraorbital cathode placement. Small-anode decreased the electric field magnitude by almost one-tenth but still got a similar statistically significant $(\mathrm {P}<0.05)$ increase in the cortical excitability (MEP) at the targeted leg motor area when compared to sham tDCS. Since the electric field magnitude was similar at the scalp (skin-electrode interface) level but differed significantly at the leg motor area in the inter-hemispheric fissure, so a possible contribution of scalp sensory nerve responses to electrocutaneous stimulation is proposed.