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Related Experiment Videos

Thirst in Brattleboro rats.

L M Fuller1, J T Fitzsimons

  • 1Physiological Laboratory, University of Cambridge, United Kingdom.

The American Journal of Physiology
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

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Brattleboro rats, lacking vasopressin, show heightened thirst responses to challenges involving the renin-angiotensin system. Their drinking behavior is more sensitive to stimuli like angiotensin II and captopril compared to normal rats.

Area of Science:

  • Physiology
  • Neuroendocrinology
  • Renal Physiology

Background:

  • Brattleboro rats exhibit thirst due to vasopressin deficiency, leading to elevated plasma osmolality, renin, and angiotensin II (ANG II).
  • Understanding thirst mechanisms in these rats is crucial for elucidating the role of the renin-angiotensin system in fluid balance.

Purpose of the Study:

  • To investigate the responsiveness of Brattleboro rats to cellular and extracellular thirst stimuli.
  • To compare the thirst response of Brattleboro rats to control strains, considering baseline water intake and fluid losses.

Main Methods:

  • Administration of hypertonic NaCl, intracranial injections of renin-angiotensin peptides and captopril, and isoproterenol in Brattleboro rats and controls.
  • Nephrectomy and ureteric ligation were used to prevent fluid losses during certain experimental conditions.

Related Experiment Videos

  • Measurement of water intake in response to various thirst stimuli and pharmacological interventions.

    • Main Results:

    • Brattleboro rats drank more in response to hypertonic NaCl but not when fluid losses were prevented.
    • Intracranial administration of renin, angiotensin I, and angiotensin II induced drinking in Brattleboro rats, with similar dose-response curves to controls.
    • Captopril and isoproterenol demonstrated enhanced thirst responses in Brattleboro rats, particularly when fluid losses were controlled.

    Conclusions:

    • The renin-angiotensin system in Brattleboro rats is more responsive to renin-dependent thirst challenges than in normal controls.
    • Vasopressin deficiency in Brattleboro rats may lead to an augmented sensitivity of the renin-angiotensin system in regulating thirst.
    • These findings highlight the complex interplay between vasopressin and the renin-angiotensin system in controlling water intake and fluid homeostasis.