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Related Concept Videos

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Antibody Structure01:10

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
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Membrane Domains01:18

Membrane Domains

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The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
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Three Developmental Domains01:29

Three Developmental Domains

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Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
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Three-Domain System of Life01:21

Three-Domain System of Life

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Ribosomal RNA (rRNA) sequence analysis revealed three distinct groups of cells: eukaryotes, bacteria, and archaea. In 1978, Carl R. Woese proposed the concept of domains, a taxonomic level above kingdoms, to differentiate these groups. He suggested that archaea and bacteria, despite their similar appearance, represent separate domains. Domains differ in rRNA, membrane lipid structure, transfer RNA, and antibiotic sensitivity.In this classification, animals, plants, and fungi belong to the...
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Conservation of Protein Domains02:26

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Updated: Feb 2, 2026

Immunization of Alpacas Lama pacos with Protein Antigens and Production of Antigen-specific Single Domain Antibodies
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sdAb-DB: The Single Domain Antibody Database.

Emily E Wilton1, Michael P Opyr2, Senthilkumar Kailasam1

  • 1Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry , University of Lethbridge , Lethbridge , Alberta T1K 3M4 , Canada.

ACS Synthetic Biology
|November 17, 2018
PubMed
Summary
This summary is machine-generated.

The new Single Domain Antibody Database (sdAb-DB) offers a free, open-source repository for single domain antibodies. It provides curated data and tools to aid researchers in synthetic biology and bioengineering.

Keywords:
bioengineeringdatabasenanobodyopen-sourcesingle domain antibody (sdAb)synthetic biology

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Area of Science:

  • Biotechnology
  • Structural Biology
  • Immunology

Background:

  • Single domain antibodies (sdAbs) are valuable tools in synthetic biology and bioengineering due to their unique properties.
  • Existing sdAb data is fragmented, hindering effective use, sharing, and engineering of these proteins.

Purpose of the Study:

  • To establish the first freely available, centralized repository for single domain antibodies and related proteins.
  • To provide researchers with easy access to curated sequences and experimental data for sdAbs.
  • To support the rational design and engineering of novel sdAb-based therapeutics and tools.

Main Methods:

  • Development of a publicly accessible, open-source database (sdAb-DB).
  • Manual curation of sdAb data from public protein databases, scientific literature, and user submissions.
  • Integration of basic bioinformatic tools for data analysis and protein engineering.

Main Results:

  • The sdAb-DB is launched as a comprehensive resource for the scientific community.
  • The database offers access to manually curated data on existing and engineered sdAbs.
  • Includes performance data and bioinformatic tools to facilitate sdAb research and development.

Conclusions:

  • The sdAb-DB serves as a crucial platform for advancing research and development in single domain antibody technology.
  • Facilitates the sharing and utilization of sdAb resources, accelerating innovation in biotechnology and bioengineering.
  • Empowers researchers with data and tools for the design and engineering of next-generation sdAb applications.