Related Experiment Video
Updated: Feb 2, 2026

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
Prolonged slow expiration technique improves recovery from acute bronchiolitis in infants: FIBARRIX randomized
Enrique Conesa-Segura1, Susana B Reyes-Dominguez2, José Ríos-Díaz3,4
11 Programa de Doctorado en Ciencias de la Salud, Universidad Católica de Murcia (UCAM), Murcia, Spain.
Insights
Prolonged slow expiration physiotherapy significantly reduces acute bronchiolitis severity in infants. This treatment also shortens hospital stays without affecting oxygen saturation, offering a safe and effective intervention for pediatric respiratory illness.
Area of Science:
- Pediatric Respiratory Medicine
- Physiotherapy Interventions
- Infant Health
Background:
- Acute bronchiolitis is a common viral respiratory infection in infants, frequently leading to hospitalization.
- Current management often focuses on supportive care, with limited evidence for specific physiotherapy interventions.
- The need for effective treatments to reduce symptom severity and hospital stay duration is critical.
Purpose of the Study:
- To evaluate the impact of prolonged slow expiration (PSE) respiratory physiotherapy on the severity of acute bronchiolitis in infants.
- To assess changes in oxygen saturation and hospital length of stay following PSE physiotherapy.
- To determine the safety and efficacy of PSE physiotherapy as an intervention for acute bronchiolitis.
Main Methods:
- A randomized controlled trial was conducted with 80 infants diagnosed with acute bronchiolitis.
- Participants were assigned to either respiratory treatment (RT) with PSE physiotherapy or standard care (control) for one week.
- Primary outcomes included the Acute Bronchiolitis Severity Scale (ABSS) score, oxygen saturation, and hospital stay duration.
Main Results:
- The PSE physiotherapy group showed significantly lower ABSS scores at multiple time points post-intervention compared to the control group.
- No significant changes in oxygen saturation were observed between the groups.
- Infants receiving PSE physiotherapy had a shorter average hospital stay, with a reduced number of days to reach an ABSS score below 2.
Conclusions:
- Prolonged slow expiration physiotherapy is effective in reducing the severity of acute bronchiolitis in infants.
- This physiotherapy technique does not adversely affect oxygen saturation levels.
- PSE physiotherapy leads to shorter hospitalizations for infants with acute bronchiolitis, indicating a beneficial role in clinical management.
Objective::
To examine the effect of prolonged slow expiration respiratory physiotherapy treatment on the acute bronchiolitis severity scale and O2 saturation at short-time and at medical discharge in infants and the hospital stay.
Design::
Randomized controlled trial.
Setting::
Infants' unit of university hospital.
Participants::
Infants with acute bronchiolitis ( N = 80).
Intervention::
Infants were randomized into respiratory treatment (RT) with prolonged slow expiration or treatment as usual (control) for one-week period.
Main Outcome Measures::
The primary outcomes were Acute Bronchiolitis Severity Scale score and O2 saturation, recorded shortly after each intervention during the stay and at medical discharge, and the hospital stay.
Results::
The RT had a significantly lower Acute Bronchiolitis Severity Scale 10-minute after the first intervention (mean difference -1.7 points, 95% confidence interval (CI) -3.0 to -0.38), 2 hours after (-2.0 points, 95% CI -3.2 to -0.86) and the last day before medical discharge (-1.3 points, 95% CI -2.1 to 0.51). No changes were detected in O2 saturation. The survival analysis of time at medical discharge showed decrease in the average number of days to achieve an Acute Bronchiolitis Severity Scale of less than 2 points (RT: 2.6 days, 95% CI 2.1-3.1; Control: 4.4 days, 95% CI 3.6-5.1).
Conclusion::
A prolonged slow expiration physiotherapy reduces Acute Bronchiolitis Severity Scale scores and does not change O2 saturation. Infants in RT group stay less days in hospital than infants in control group and no adverse events were detected.
More Related Videos
Related Concept Videos
Mechanism of Breathing II: Expiration
Expiration, or exhaling, is a complex physiological process that begins as the inspiratory muscles begin to relax. This relaxation triggers a series of events that epitomize the efficiency of the respiratory system.
Mechanism of Expiration:
Clinical Trials: Overview
Trial and Error and Algorithm
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Gene Evolution - Fast or Slow?
Clinical Trials
There are four phases in a clinical trial. A phase one...

