Quality of life in patients with toe-to-hand transplantation

Toe-to-hand transplantation is a reliable procedure that replaces like-with-like in cases of a lost thumb or finger. The aim of this study is to investigate the effects of toe transplantation on patients from the perspectives of quality of life (QOL) and disability.

Ten patients with traumatic amputation of a digit underwent reconstruction with toe transplantation. The mean age at injury was 40.2 years (range 17-59 years). Reconstructive options were 5 wrap-around flaps to 2 thumbs and 3 index fingers; 2 second-toe transplantations to 2 middle fingers, and 3 hemipulp-free flaps from the great toe to a thumb and an index finger. We hypothesized that toe transplantation would improve postoperative QOL and disability. Outcome assessments included completion of the SF-36, SAFE-Q, and DASH questionnaires before and after reconstruction. Scores on each test were calculated and intra-individual comparisons were made.

All scores for the eight SF-36 health domains improved, with a significant difference in Vitality from before to after surgery. In contrast, scores for all five SAFE-Q items worsened, with significant changes for the 'Pain and Pain-Related' and 'Physical Functioning and Daily Living' subscales. DASH scores improved after surgery in all cases.

Our results suggest that toe-to-hand transplantation for amputated finger reconstruction is a good option in terms of improved QOL. However, worsened SAFE-Q scores imply that donor site problems could be expected and must be taken into account during surgical planning.