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Anesthesiological risks in mucopolysaccharidoses.

Alessandra Moretto1, Maria Grazia Bosatra2, Laura Marchesini3

  • 1Department of Perioperative Medicine and Intensive Care, ASST San Gerardo, Via Pergolesi 33, 20900, Monza, MB, Italy. alessandramoretto62@gmail.com.

Italian Journal of Pediatrics
|November 17, 2018
PubMed
Summary
This summary is machine-generated.

Anesthesia for mucopolysaccharidosis (MPS) patients requires careful airway management due to high risks. Utilizing experienced teams and advanced tools like videolaryngoscopes enhances safety for these complex cases.

Keywords:
Airway managementAnesthesiaMucopolysaccharidosisPerioperative complications

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Area of Science:

  • Anesthesiology
  • Rare Diseases
  • Genetics

Background:

  • Mucopolysaccharidosis (MPS) patients present significant anesthetic challenges, particularly concerning airway management.
  • Existing evidence is largely based on case reports and small series, limiting comprehensive guidance.

Purpose of the Study:

  • To compile and synthesize existing literature on airway management strategies for various mucopolysaccharidosis subtypes.
  • To provide anesthesiologists with a practical guide for optimizing airway management in MPS patients.

Main Methods:

  • Conducted a systematic literature search of PubMed using keywords related to anesthesia and mucopolysaccharidosis, including difficult airway management.
  • Included case reports offering practical suggestions for preoperative evaluation, risk assessment, and perioperative planning.

Main Results:

  • Reviewed 15 reviews, 17 case series, 5 prospective studies, and 28 case reports focusing on airway management.
  • Preoperative evaluation and experienced teams are crucial for all MPS types.
  • Laryngeal mask airway insertion and videolaryngoscopy facilitate ventilation and intubation.

Conclusions:

  • Anesthetic management of MPS patients carries high risks but can be improved with a multidisciplinary approach.
  • Expertise in new airway management techniques and devices enhances patient safety.
  • Further prospective studies are recommended to strengthen the evidence base.