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The effect of dopamine on renal function during aortic cross clamping
M G Salem1, J W Crooke, G A McLoughlin
1Halton General Hospital, Runcorn, Cheshire.
Annals of the Royal College of Surgeons of England
|January 1, 1988
Summary
Dopamine infusion during abdominal aortic surgery cross-clamping significantly improved kidney function by increasing urine output and creatinine clearance. This suggests dopamine protects kidneys from clamping-related damage.
Area of Science:
- Nephrology
- Cardiovascular Surgery
- Pharmacology
Background:
- Abdominal aortic surgery often involves cross-clamping, which can impair renal blood flow and function.
- Kidney protection during this procedure is crucial to prevent postoperative complications.
Purpose of the Study:
- To investigate the effect of intraoperative dopamine infusion on renal function during abdominal aortic surgery.
Main Methods:
- Eighteen male patients undergoing elective abdominal aortic reconstruction were studied.
- Patients received dopamine (2 mcg/kg/min) during either the first or second half of aortic cross-clamping, acting as their own controls.
- Renal function parameters including urine output, sodium output, potassium output, and creatinine clearance were measured during pre-clamp, dopamine-treated clamping, and non-dopamine clamping periods.
Main Results:
- Dopamine infusion during aortic clamping led to a significant increase in sodium output (P < 0.01).
- Significant increases were also observed in potassium output (P < 0.05), creatinine clearance (P < 0.05), and urine output (P < 0.05).
Conclusions:
- Intraoperative dopamine administration during aortic cross-clamping demonstrates a protective effect on renal function.
- Dopamine infusion can mitigate the adverse effects of aortic clamping on the kidneys, enhancing urine output and filtration markers.