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Mitral valve prolapse--a review.

K H Leong¹, A T Tan, S S Quek

¹Department of Cardiology, Singapore General Hospital.

Annals of the Academy of Medicine, Singapore

|April 1, 1988

Summary

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Mitral valve prolapse affects 5-15% of the community, with prevalence varying by age and sex. Familial clustering suggests a potential genetic component, possibly autosomal dominant inheritance.

Area of Science:

Cardiology
Genetics

Background:

Mitral valve prolapse (MVP) is a common cardiac condition.
Prevalence estimates vary widely (5-15%) due to diagnostic and population differences.
Age-related prevalence patterns differ between sexes.

Purpose of the Study:

To summarize the current understanding of mitral valve prolapse prevalence.
To explore demographic variations and potential genetic factors.

Main Methods:

Review of community-based prevalence data.
Analysis of age and sex-specific prevalence.
Examination of familial aggregation and inheritance patterns.

Main Results:

Estimated community prevalence of 5-15%.

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Decreased prevalence in older females, unlike males.

30% of individuals with MVP have affected relatives.

Conclusions:

Mitral valve prolapse exhibits variable prevalence.
Genetic factors, potentially autosomal dominant, may influence MVP.
Age and other factors likely modify disease expression.