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Fertility and Ovarian Reserve among Women with Rheumatoid Arthritis
Amanda M Eudy1,2, Gary McDaniel3,4, William W Hurd3,4
1From the Division of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA. amanda.eudy@duke.edu.
Objective:
We sought to identify causes for infertility in women with and without rheumatoid arthritis (RA).
Methods:
Women with RA were matched to healthy controls. Differences in anti-Müllerian hormone (AMH) and anovulation were analyzed.
Results:
Women with RA had lower AMH (β -1.05, 95% CI -2.09 to -0.005), but no difference was observed when AMH was log-transformed. No difference in anovulation was observed. Infertility prevalence was similar between groups, primarily attributable to polycystic ovary syndrome in healthy controls but largely unexplained in women with RA.
Conclusion:
AMH was lower in women with RA, but reasons for infertility among women with RA remain unknown.
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