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Early Post-stroke Depression and Mortality: Meta-Analysis and Meta-Regression
Francesco Bartoli1, Carmen Di Brita1, Cristina Crocamo1
1Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Early post-stroke depression (PSD) significantly increases mortality risk. This systematic review found that individuals experiencing depression within three months of a stroke have a 50% higher mortality rate.
Area of Science:
- Neurology
- Psychiatry
- Public Health
Background:
- Post-stroke depression (PSD) is a frequent and severe complication following a stroke.
- Early onset of depressive symptoms (within 3 months) is a critical concern.
Purpose of the Study:
- To systematically review and meta-analyze the association between early PSD and mortality.
- To quantify the risk of mortality in stroke survivors with early PSD.
Main Methods:
- Systematic review and meta-analysis adhering to MOOSE guidelines.
- Inclusion of seven studies with over 119,000 participants.
- Pooled relative risk (RR) estimation using a random-effects model.
Main Results:
- Individuals with early PSD exhibited a 50% increased mortality risk (RR = 1.50; 95% CI: 1.28-1.75).
- Short-term mortality risk was higher (RR = 1.70) compared to long-term risk (RR = 1.35).
- Meta-regression indicated sample proportion of men influenced the estimate.
Conclusions:
- Early PSD negatively impacts survival rates post-stroke.
- Further research is needed to elucidate underlying mechanisms.
- Early depression management may improve post-stroke life expectancy.
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