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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
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MicroRNAs: Pleiotropic Regulators in the Tumor Microenvironment
Ning Yang1, Shan Zhu1, Xinping Lv1
1Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, China.
Frontiers in Immunology
|November 17, 2018
Summary
MicroRNAs (miRNAs) regulate gene expression and are implicated in disease. This review explores how altered miRNAs in the tumor microenvironment (TME) drive cancer progression and influence cell crosstalk, aiding miRNA-based therapy development.
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
- Aberrant miRNA expression is linked to human diseases, including cancer.
- The tumor microenvironment (TME) involves complex cell-cell interactions influencing tumor progression.
Purpose of the Study:
- To review the role of aberrantly expressed miRNAs in tumor progression.
- To summarize miRNA-mediated crosstalk within the TME.
- To highlight the therapeutic potential of miRNAs in cancer treatment.
Main Methods:
- Literature review of studies on miRNAs in cancer.
- Analysis of miRNA involvement in TME cell communication.
- Synthesis of current knowledge on miRNA-based cancer therapies.
Main Results:
- Altered miRNA expression in stromal and tumor cells can drive tumorigenesis.
- miRNAs mediate crosstalk between tumor cells, immune cells, CAFs, and CAEs.
- Dysregulated miRNAs significantly impact tumor progression and the TME.
Conclusions:
- miRNAs are critical regulators within the tumor microenvironment.
- Understanding miRNA roles in cell crosstalk is key for targeted therapies.
- miRNA-based therapeutics show promise for clinical application in cancer treatment.
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