Related Experiment Video

Updated: Feb 2, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

5.1K

Long Pentraxin 3-Mediated Fibroblast Growth Factor Trapping Impairs Fibrosarcoma Growth

Priscila Fabiana Rodrigues1, Sara Matarazzo2, Federica Maccarinelli2

  • 1Laboratory of Inflammation and Cancer, Department of General Biology - ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Frontiers in Oncology
|November 17, 2018
PubMed

Insights

Long pentraxin-3 (PTX3) acts as an oncosuppressor by inhibiting fibroblast growth factor-2 (FGF2) signaling. PTX3 overexpression or FGF trap molecules show therapeutic potential against fibrosarcoma by reducing tumor growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Fibrosarcomas are malignant soft tissue tumors driven by fibroblast growth factor-2 (FGF2) and its receptors (FGFRs).
  • Long pentraxin-3 (PTX3) is an oncosuppressor that inhibits FGF signaling but is downregulated in tumors, including soft tissue sarcomas, due to gene promoter hypermethylation.

Purpose of the Study:

  • To investigate the therapeutic potential of PTX3 and FGF trap molecules in fibrosarcoma.
  • To evaluate the impact of PTX3 on fibrosarcoma cell proliferation and tumor growth.

Main Methods:

  • Assessed PTX3 effects on fibrosarcoma cells in vitro and in vivo.
  • Utilized transgenic mice for systemic PTX3 delivery.
  • Tested the efficacy of the PTX3-derived small molecule FGF trap, NSC12, in fibrosarcoma models.

Main Results:

  • PTX3 overexpression significantly reduced fibrosarcoma cell proliferation and tumorigenicity.
  • Systemic PTX3 delivery inhibited fibrosarcoma graft growth in mice.
  • NSC12 prevented FGF/FGFR activation and reduced fibrosarcoma tumor activity.

Conclusions:

  • PTX3 acts as a potent inhibitor of fibrosarcoma growth.
  • Targeting the FGF/FGFR system with FGF trap molecules represents a promising therapeutic strategy for fibrosarcoma treatment.
Keywords:
FGFFGF-trapFGFRfibrosarcomalong pentraxin-3

More Related Videos

Author Spotlight: Optimizing Growth Factors for Production of Biotechnologically Relevant Secondary Metabolites06:20

Author Spotlight: Optimizing Growth Factors for Production of Biotechnologically Relevant Secondary Metabolites

Published on: October 25, 2024

2.9K
In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures10:45

In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures

Published on: October 14, 2021

4.1K

Related Concept Videos

Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.9K
Factors Influencing Microbial Growth: pH01:29

Factors Influencing Microbial Growth: pH

Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.2K
Population Growth00:57

Population Growth

Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.6K
Factors Influencing Microbial Growth: Temperature01:27

Factors Influencing Microbial Growth: Temperature

Microorganisms display remarkable adaptations, enabling them to thrive in diverse ecological niches across a wide range of temperatures. Temperature profoundly influences microbial growth by affecting enzymatic activity, membrane fluidity, and other cellular processes.Each microorganism operates within a specific temperature range defined by three cardinal points: minimum, optimum, and maximum. Below the minimum temperature, membranes lose fluidity, halting transport processes. Above the...
1.3K
Factors Influencing Microbial Growth: Osmolarity01:28

Factors Influencing Microbial Growth: Osmolarity

Osmolarity is the measure of solute concentration in a solution. It plays a critical role in determining water availability for organisms. Water moves across semipermeable membranes through osmosis, flowing from regions of lower solute concentration (more dilute) to regions of higher solute concentration (more concentrated).In high-solute environments, microbial cells lose water, leading to dehydration and inhibited growth. The extent to which water is available to microbes in such environments...
874
Meristems and Plant Growth02:36

Meristems and Plant Growth

Plants grow throughout their lives; this is called indeterminate growth, and it distinguishes plants from most animals. Although certain parts of plants stop growing (e.g., leaves and flowers), others grow continuously—like roots and stems.
49.5K