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Related Concept Videos

Dry Friction01:30

Dry Friction

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Dry friction occurs between two solid surfaces in contact as they attempt to move relative to one another. In daily life, dry friction is encountered in various forms, such as when walking on the ground, sliding an object across a table, or rubbing hands together. Despite its ubiquity, the underlying mechanisms behind dry friction are not readily visible.
To illustrate this concept, imagine a wooden crate resting on a rough, non-uniform horizontal surface. When an external force is applied to...
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Drying Shrinkage01:21

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When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
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Characteristics of Dry Friction01:21

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Dry friction occurs when two solid surfaces slide against each other without any lubrication or fluid present. It causes resistance when pushing objects along a surface, like a gardener pushing a wheelbarrow. The force applied to move the cart causes dry friction between the wheel and the ground.
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Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...
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After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...
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Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
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Single Port Donor Nephrectomy
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Single-donor spray-dried plasma.

Qiyong Peter Liu1, Ryan Carney1, Jihae Sohn1

  • 1Velico Medical, Inc., Beverly, Massachusetts.

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|November 17, 2018
PubMed
Summary
This summary is machine-generated.

Spray-dried plasma (ODP) offers logistical advantages for hemostasis management and demonstrates comparable coagulation function to fresh frozen plasma (FFP). This novel method is suitable for blood center implementation, enabling on-demand plasma availability.

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Area of Science:

  • Biomedical Engineering
  • Hematology
  • Blood Banking

Background:

  • Dried plasma offers logistical advantages over fresh frozen plasma (FFP) for hemostasis management.
  • Velico Medical developed a spray-drying system for producing on-demand plasma (ODP).
  • This study evaluates the quality of ODP compared to FFP.

Purpose of the Study:

  • To compare the quality and coagulation function of spray-dried plasma (ODP) with fresh frozen plasma (FFP).
  • To assess the feasibility of implementing spray-drying technology in blood centers.

Main Methods:

  • Sixty units of ODP were manufactured from fresh plasma, pretreated, and spray-dried.
  • Paired aliquots of plasma were stored as ODP or FFP.
  • ODP and FFP were reconstituted and characterized in parallel after 31-33 days.

Main Results:

  • ODP exhibited comparable global coagulation function to FFP, assessed by activated partial thromboplastin time and prothrombin time.
  • Functional coagulation factors and related proteins in ODP were >80% of FFP levels, with Factor XIII at 74%.
  • Pretreatment preserved von Willebrand factor multimers, retaining 60% vWF:ristocetin cofactor activity.

Conclusions:

  • On-demand plasma (ODP) demonstrates comparable coagulation function to fresh frozen plasma (FFP).
  • The spray-drying system is implementable in blood centers for ODP production.