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A second KRT71 allele in curly coated dogs
A Bauer1,2, S Hadji Rasouliha1,2, M T Brunner2,3
1Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, 3001, Switzerland.
Animal Genetics
|November 17, 2018
Summary
A new KRT71 gene variant explains curly coats in dogs, distinct from the previously known allele. This discovery offers insights into canine coat genetics and potential hair follicle development issues.
Area of Science:
- Genetics
- Canine genetics
- Molecular biology
Background:
- Coat variation in dogs is often linked to specific gene variants.
- A known KRT71 gene variant (p.Arg151Trp) causes curly hair, but doesn't explain all cases.
Purpose of the Study:
- To identify novel genetic variants responsible for curly coats in dog breeds lacking the known KRT71 mutation.
- To investigate the role of the KRT71 gene in canine hair morphology.
Main Methods:
- Whole-genome sequencing of a Curly Coated Retriever.
- Variant analysis of the KRT71 gene.
- Sanger sequencing to confirm variant presence in a larger cohort and control breeds.
Main Results:
- A novel indel variant (NM_001197029.1:c.1266_1273delinsACA) in KRT71 exon 7 was identified, causing a frameshift and altered protein.
- This variant was homozygous in the sequenced Curly Coated Retriever and absent/heterozygous in control dogs.
- The variant was fixed in 125 Curly Coated Retrievers and found in 5 of 14 other curly/wavy-coated breeds.
Conclusions:
- A second KRT71 gene variant is identified as a cause of curly hair in dogs.
- This new variant may result in a distinct coat phenotype and could be linked to follicular dysplasia.
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