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Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy
Zheng-Yu Jiang1,2, Meng-Chen Lu1,2, Qi-Dong You1,2
1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China.
Abstract:
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a pleiotropic transcription factor, especially for its complex and dual effects in cancer. With the continuous growing research, new regulatory modes and new functions of Nrf2 and tumor-promoting effects of Nrf2 in malignant transformed tumors have become increasingly clear. Accumulating evidence has established that Nrf2 contributes to the whole process of pathogenesis, progression, metastasis, and prognosis of cancer, and Nrf2 could be a promising target in cancer therapy. However, the development of Nrf2 inhibitor is still limited. In this perspective, we will briefly describe the biological function and modulating network of Nrf2, stress its oncogenic role, and point out possible ways to inhibit Nrf2, as well as summarize the reported Nrf2 inhibitors.
Insights
Nuclear factor erythroid 2-related factor 2 (Nrf2) promotes cancer progression and metastasis. Inhibiting Nrf2 presents a promising therapeutic strategy, though Nrf2 inhibitors are still under development.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor with complex roles in cancer.
- Emerging research highlights Nrf2's tumor-promoting functions in malignant tumors.
Purpose of the Study:
- To elucidate the biological function and regulatory network of Nrf2 in cancer.
- To emphasize the oncogenic role of Nrf2.
- To explore potential strategies for Nrf2 inhibition and review existing inhibitors.
Main Methods:
- Literature review and synthesis of current research on Nrf2 in cancer.
- Analysis of Nrf2's involvement in cancer pathogenesis, progression, metastasis, and prognosis.
- Review of documented Nrf2 inhibitors and their development status.
Main Results:
- Nrf2 significantly contributes to cancer development, progression, metastasis, and patient prognosis.
- The oncogenic role of Nrf2 is increasingly evident, making it a potential therapeutic target.
- Development of effective Nrf2 inhibitors remains a challenge.
Conclusions:
- Nrf2 plays a critical role in multiple stages of cancer, indicating its potential as a therapeutic target.
- Further research into Nrf2 inhibitors is crucial for advancing cancer therapy.
- Understanding Nrf2's complex functions is key to developing targeted cancer treatments.
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