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A Quantitative Fluorescence Microscopy-based Single Liposome Assay for Detecting the Compositional Inhomogeneity Between Individual Liposomes
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Long circulating liposomes: challenges and opportunities.

Suyash Deodhar1, Alekha K Dash1

  • 1Department of Pharmacy Sciences, School of Pharmacy & Health Professions, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.

Therapeutic Delivery
|November 17, 2018
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Summary
This summary is machine-generated.

Poly(ethylene glycol)-modified liposomes improve anticancer drug delivery but can cause allergic reactions. This review explores challenges and solutions for long-circulating liposomes in cancer therapy.

Keywords:
PEGylationligand selective retentionliposomessurface modification

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Area of Science:

  • Nanotechnology in Medicine
  • Pharmaceutical Sciences
  • Oncology Drug Delivery

Background:

  • Poor pharmacokinetic parameters and low solubility of anticancer drugs necessitate advanced drug delivery systems.
  • Conventional liposomes face limitations, leading to the development of targeted and long-circulating formulations.
  • Poly(ethylene glycol) (PEG)ylation enhances liposome circulation time and stability.

Purpose of the Study:

  • To review the challenges and limitations associated with long-circulating liposomes, particularly PEGylated liposomes.
  • To explore potential strategies and opportunities for overcoming the identified hindrances in liposomal drug delivery.

Main Methods:

  • Literature review of studies on liposomal drug delivery systems for anticancer therapeutics.
  • Analysis of the impact of poly(ethylene glycol) modification on liposome pharmacokinetics and immunogenicity.
  • Examination of targeted ligand strategies for enhanced liposome retention and cellular uptake.

Main Results:

  • PEGylated liposomes demonstrate improved circulation times, enhancing therapeutic efficacy.
  • A significant challenge is the allergenic response associated with PEGylated liposomes, even in naive patients.
  • Ligand-targeted liposomes show potential for selective retention and uptake, but require further investigation.

Conclusions:

  • Long-circulating liposomes, while beneficial for anticancer drug delivery, present immunogenicity challenges.
  • Overcoming the allergenic potential of PEGylated liposomes is crucial for their broader clinical application.
  • Future research should focus on developing safer, next-generation liposomal formulations with improved targeting and reduced immunogenicity.