Related Experiment Video
Updated: Feb 2, 2026
23:06
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
19.6K
Multidrug-resistant Gram-negative osteomyelitis: a 10-year study
Il Giornale Di Chirurgia
|November 17, 2018
Summary
This study analyzed multi-drug resistant (MDR) and extensively-drug resistant (XDR) gram-negative osteomyelitis cases. Effective antimicrobial strategies combined with surgery are crucial for managing these challenging infections.
Area of Science:
- Infectious Diseases
- Orthopedic Surgery
- Microbiology
Background:
- Osteomyelitis caused by multi-drug resistant (MDR) and extensively-drug resistant (XDR) gram-negative bacteria presents a significant clinical challenge.
- Limited data exists on the management and outcomes of such infections.
Purpose of the Study:
- To investigate the causative organisms, surgical and medical management strategies, and outcomes of MDR and XDR gram-negative bacterial osteomyelitis.
- To highlight the importance of antimicrobial stewardship in treating resistant infections.
Main Methods:
- Retrospective evaluation of 14 patients with acute osteomyelitis caused by MDR or XDR gram-negative pathogens treated between 2007 and 2016.
- Analysis of causative pathogens, patient demographics, comorbidities, treatment regimens, and outcomes.
Main Results:
- Common pathogens included Acinetobacter baumanii, Klebsiella pneumoniae, Enterobacter cloacae, Escherichia coli, and Pseudomonas aeruginosa.
- Most infections were hospital-acquired; comorbidities like smoking, diabetes, and injury were prevalent.
- All patients received empirical combination antimicrobial treatment, with 13 undergoing surgical intervention.
Conclusions:
- Antimicrobial therapy is a vital adjunct to surgical treatment for acute osteomyelitis.
- Strict adherence to antimicrobial strategies is paramount due to the increasing prevalence of resistant microorganisms.
More Related Videos
09:29In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
Published on: April 28, 2017
9.9K
08:19Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
Published on: July 7, 2020
11.4K
Related Concept Videos
01:17Gram-negative Bacterial Protein Secretion Systems
918
Gram-negative bacteria utilize sophisticated protein secretion systems to transport proteins across their double-membrane envelope into the extracellular environment or host cells. Based on their mechanism of action, these systems are classified into one-step and two-step pathways.One-Step Secretion Systems (Types I, III, IV, and VI)One-step secretion systems bypass the periplasm entirely, forming a continuous channel that spans both the inner and outer membranes:Type I Secretion System (T1SS):...
918
01:26Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture
663
Sputum studies are a critical part of diagnosing and treating numerous respiratory conditions. These studies involve obtaining sputum samples for analysis to identify pathogenic organisms and assess the presence of abnormal cells indicative of malignant conditions. This lesson will delve into three fundamental sputum studies: Gram Stain, Cytology, and Acid-fast Smear and Culture.
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
663
01:23Negative Regulator Molecules
38.5K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.5K
00:58Positive, Negative, and Zero Work
22.2K
Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.2K
01:22Resistivity
4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
01:19Resistance
6.0K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K