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Drug-induced cholestasis.

D Larrey, S Erlinger

    Bailliere'S Clinical Gastroenterology
    |April 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    Drug-induced cholestasis, a liver injury, often resolves within six months. Some cases, like prolonged ductular cholestasis or floxuridine-induced cholangitis, have unique mechanisms and prognoses.

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    Area of Science:

    • Hepatology
    • Toxicology
    • Gastroenterology

    Background:

    • Drug-induced liver injury (DILI) commonly presents as hepatocellular cholestasis.
    • Hormonal steroids and psychotropic medications are frequent culprits.
    • Cholestasis typically resolves within six months, but prolonged forms exist.

    Purpose of the Study:

    • To review the clinical presentations and outcomes of various drug-induced cholestasis syndromes.
    • To discuss the potential pathogenetic mechanisms, including immunoallergic and autoimmune factors.
    • To highlight the distinct features and prognosis of prolonged ductular cholestasis and floxuridine-induced sclerosing cholangitis.

    Main Methods:

    • Literature review of drug-induced cholestasis cases.
    • Analysis of clinical features, drug associations, and outcomes.

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  • Discussion of proposed pathogenetic mechanisms.

    • Main Results:

    • Acute drug-induced cholestasis usually resolves promptly upon drug withdrawal.
    • Prolonged ductular cholestasis, mimicking primary biliary cirrhosis, can occur but is often reversible.
    • Floxuridine-induced sclerosing cholangitis is a severe complication with a poor prognosis.

    Conclusions:

    • Drug-induced cholestasis encompasses diverse clinical entities with varying prognoses.
    • Immunoallergic and autoimmune mechanisms are implicated in some forms.
    • Prompt diagnosis and drug withdrawal are crucial, though some cases require specific management strategies.