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Multichannel digital heteronuclear magnetic resonance biosensor.

Stephan Huber1, Changwook Min2, Christoph Staat3

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A new system, HERMES, enables high-throughput nuclear magnetic resonance (NMR) analysis by creating multiple virtual NMR consoles. This allows for rapid, parallel detection from multiple samples, overcoming limitations of traditional single-channel NMR systems.

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BiosensorMagnetic sensorNuclear magnetic resonance

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Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Biophysical Chemistry
  • Analytical Chemistry

Background:

  • Low-field, mobile NMR systems offer broad applications but are limited by single-channel detection, restricting throughput and increasing complexity.
  • Current multi-channel NMR approaches involve serial probe access or redundant electronics, leading to long assay times and system bulkiness.

Purpose of the Study:

  • To introduce HERMES (hetero-nuclear resonance multichannel electronic system), a scalable architecture for versatile, high-throughput NMR analyses.
  • To overcome the limitations of conventional single-channel NMR systems through a novel digital virtualization approach.

Main Methods:

  • HERMES utilizes software-defined radio principles to virtualize NMR electronics in the digital domain, creating multiple NMR consoles without additional hardware.
  • The system enables parallel acquisition from multiple NMR channels across wide frequency ranges within a single compact device.
  • HERMES was interfaced with an array of NMR probes for simultaneous multi-sample measurements and hetero-nuclear spin analysis (¹H, ¹⁹F, ¹³C).

Main Results:

  • Simultaneous measurement of NMR relaxation from multiple samples was achieved.
  • Resolution of hetero-nuclear spin spectra (¹H, ¹⁹F, ¹³C) was demonstrated.
  • The system successfully detected dengue fever and profiled cancer cells via multi-channel protein assays, showcasing diagnostic potential.

Conclusions:

  • HERMES provides a scalable, high-throughput solution for NMR analyses by enabling on-demand, parallel detection.
  • The virtualization strategy significantly enhances NMR system functionality, reducing complexity and assay times.
  • HERMES shows promise as a powerful, reconfigurable analytical tool for diverse applications, including medical diagnostics.