Related Experiment Video

Updated: Feb 2, 2026

Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
07:02

Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice

Published on: August 24, 2011

15.6K

Modified frailty index predicts postoperative outcomes of spontaneous intracerebral hemorrhage

Yukihiro Imaoka1, Takayuki Kawano2, Akihito Hashiguchi3

  • 1Department of Neurosurgery, Hitoyoshi Medical Center, 35 Oigamicho, Hitoyoshi city, Kumamoto, 868-8555, Japan; Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto city, Kumamoto, 860-8556, Japan.

Clinical Neurology and Neurosurgery
|November 17, 2018
PubMed
Abstract

Insights

The modified frailty index (mFI) predicts poor outcomes in patients undergoing surgery for spontaneous intracerebral hemorrhage (sICH). Combining mFI with the ICH score improves prediction of postoperative results.

Area of Science:

  • Neurosurgery
  • Geriatrics
  • Critical Care Medicine

Background:

  • Frailty is a significant concern in the elderly population.
  • Spontaneous intracerebral hemorrhage (sICH) is a critical condition requiring surgical intervention.
  • Assessing preoperative risk factors is crucial for optimizing surgical outcomes.

Purpose of the Study:

  • To investigate the association between the modified frailty index (mFI) and postoperative outcomes in patients with sICH.
  • To evaluate the predictive performance of mFI compared to the established ICH score.

Main Methods:

  • A cohort of 156 patients undergoing surgery for sICH was analyzed.
  • The modified frailty index (mFI) was calculated for each patient.
  • Postoperative outcomes, including unfavorable outcomes (modified Rankin Scale 4-6) and mortality at 6-8 months, were assessed.
  • The prognostic ability of mFI was compared with the Hemphill's ICH score.

Main Results:

  • Higher mFI scores were significantly associated with unfavorable postoperative outcomes (p=0.004).
  • Elevated mFI was also a strong predictor of mortality (p<0.001).
  • The combination of the ICH score and mFI demonstrated superior discriminative ability for predicting outcomes compared to the ICH score alone.

Conclusions:

  • The modified frailty index (mFI) is a valuable and reliable predictor of postoperative outcomes in patients with sICH.
  • Frailty assessment should be a key consideration in the preoperative evaluation of elderly patients undergoing surgery for sICH.
Keywords:
FrailtyICH scoreIntracerebral hemorrhageModified frailty indexPostoperative outcomeSurgical treatment

More Related Videos

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation09:01

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

8.6K
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase10:44

Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase

Published on: September 22, 2012

25.5K

Related Concept Videos

Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Spontaneity02:21

Spontaneity

A spontaneous process is one that occurs naturally under certain conditions. A nonspontaneous process, on the other hand, will not take place unless it is “driven” by the continual input of energy from an external source. Processes have a natural tendency to occur in one direction under a given set of conditions. Water will naturally flow downhill (spontaneous process), but uphill flow (nonspontaneous process) requires outside intervention such as the use of a pump. Iron exposed to...
30.0K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries
45.8K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.2K
Prediction Intervals01:03

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.4K
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
2.3K