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Chlamydiae in human intestinal biopsy samples.

Nicole Borel1, Hanna Marti1, Andreas Pospischil1

  • 1Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, CH-8057 Zurich, Switzerland.

Pathogens and Disease
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Summary
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Chlamydia trachomatis DNA was found in intestinal biopsies, suggesting potential colonization of the gastrointestinal tract. Further research is needed to confirm if this indicates an active infection or asymptomatic carriage.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Chlamydia trachomatis is commonly found in anorectal samples.
  • A hypothesis suggests C. trachomatis may asymptomatically colonize the gastrointestinal tract as a commensal organism.

Purpose of the Study:

  • To investigate the presence of chlamydial DNA and antigen in intestinal biopsy samples.
  • To explore the hypothesis of C. trachomatis as a gastrointestinal commensal.

Main Methods:

  • Analysis of intestinal biopsy samples from patients with "chlamydia" in histopathology reports (cases) and controls.
  • Real-time PCR using 23S ribosomal RNA for Chlamydiaceae DNA detection.
  • Immunohistochemistry to identify chlamydial inclusions.

Main Results:

  • Chlamydial DNA (C. trachomatis and C. abortus) was detected in intestinal biopsies from a subset of patients.
  • Chlamydial inclusions were identified in rectal or appendiceal samples of two patients.
  • Findings in some cases were consistent with sexually acquired C. trachomatis.

Conclusions:

  • Chlamydial DNA can be detected in intestinal biopsies proximal to the anorectal site.
  • The presence of DNA/antigen does not confirm active infection; further studies are required.
  • Larger prospective studies on fresh tissue are needed to validate these findings.