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Updated: Feb 2, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
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Metabolomic Profiling of Infants With Recurrent Wheezing After Bronchiolitis

Alessia Barlotta1, Paola Pirillo1,2, Matteo Stocchero1,2

  • 1Department of Women's and Children's Health, University Hospital of Padova, Padova, Italy.

The Journal of Infectious Diseases
|November 17, 2018
PubMed

Insights

Urine metabolomic analysis can identify infants at risk for recurrent wheezing after bronchiolitis. This finding offers a novel approach to predict post-bronchiolitis wheezing in children.

Area of Science:

  • Pediatrics
  • Metabolomics
  • Respiratory Medicine

Background:

  • Bronchiolitis increases the risk of recurrent wheezing in infants.
  • Current methods cannot reliably identify infants who will develop post-bronchiolitis wheezing.

Purpose of the Study:

  • To evaluate urine metabolomic analysis for identifying infants at risk of recurrent wheezing after bronchiolitis.
  • To assess the potential of metabolomic profiling in predicting post-bronchiolitis outcomes.

Main Methods:

  • Prospective study of 52 infants (<1 year) treated for acute bronchiolitis.
  • Untargeted urine metabolomic analysis using mass spectrometry.
  • 2-year follow-up to identify recurrent wheezing (≥3 episodes).

Main Results:

  • Metabolomic profiles differentiated infants with and without post-bronchiolitis recurrent wheeze.
  • Citric acid cycle and specific amino acids (lysine, cysteine, methionine) were key differentiating factors.

Conclusions:

  • Urine metabolomic profiling is a promising tool for identifying infants at risk of recurrent wheezing post-bronchiolitis.
  • This study is the first to demonstrate the utility of urine metabolomics for this prediction.
Abstract

Keywords:
Bronchiolitiscitric acid cyclemass spectrometrymetabolomicspediatricsrecurrent wheezingurine

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