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Formation of Blood Clot
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Related Experiment Video

Updated: Feb 2, 2026

Murine Model of Wound Healing
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Macrophage functions in wound healing.

Malgorzata Kloc1,2,3, Rafik M Ghobrial1,2, Jarek Wosik4,5

  • 1Immunobiology, The Houston Methodist Research Institute, Houston, Texas, USA.

Journal of Tissue Engineering and Regenerative Medicine
|November 17, 2018
PubMed
Summary

This review explores macrophage roles in wound healing and regeneration. It covers macrophage origins, diversity, and methods to manipulate them for new therapies.

Keywords:
CX3CR1ROCK kinaseRhoAactinmacrophageswound healing

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Area of Science:

  • Regenerative Medicine
  • Immunology
  • Wound Healing Research

Background:

  • Macrophages are critical immune cells involved in tissue repair and regeneration.
  • Understanding macrophage behavior is key to improving wound healing outcomes.

Purpose of the Study:

  • To review the ontogeny, origin, and heterogeneity of macrophages in wound healing.
  • To explore methods for manipulating macrophage functions for therapeutic benefit.

Main Methods:

  • Literature review of current knowledge on macrophage biology in regeneration.
  • Analysis of genetic, pharmacologic, and bioengineering approaches.
  • Discussion of clinical applications.

Main Results:

  • Macrophages exhibit diverse origins and phenotypes during wound healing.
  • Functional plasticity allows macrophages to adapt to different healing phases.
  • Current methods offer potential for targeted macrophage-based therapies.

Conclusions:

  • Targeting macrophage phenotypes and functions holds promise for novel wound healing therapies.
  • Further research into macrophage manipulation can advance clinical regenerative strategies.