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Updated: Feb 2, 2026

Author Spotlight: Challenges in Developing Dry Eye Animal Models and Future Research Directions
Published on: February 9, 2024
TRPM8 Channels and Dry Eye
Jee Myung Yang1,2, Edward T Wei3, Seong Jin Kim4
1Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea. jeemang87@naver.com.
Abstract:
Transient receptor potential (TRP) channels transduce signals of chemical irritation and temperature change from the ocular surface to the brain. Dry eye disease (DED) is a multifactorial disorder wherein the eyes react to trivial stimuli with abnormal sensations, such as dryness, blurring, presence of foreign body, discomfort, irritation, and pain. There is increasing evidence of TRP channel dysfunction (i.e., TRPV1 and TRPM8) in DED pathophysiology. Here, we review some of this literature and discuss one strategy on how to manage DED using a TRPM8 agonist.
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