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Author Spotlight: Challenges in Developing Dry Eye Animal Models and Future Research Directions
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TRPM8 Channels and Dry Eye.

Jee Myung Yang1,2, Edward T Wei3, Seong Jin Kim4

  • 1Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Korea. jeemang87@naver.com.

Pharmaceuticals (Basel, Switzerland)
|November 18, 2018
PubMed
Summary
This summary is machine-generated.

Transient receptor potential (TRP) channels are implicated in dry eye disease (DED). This review explores managing DED with a TRPM8 agonist, targeting TRP channel dysfunction.

Keywords:
TRPM8TRPVdry eye diseasetransient receptor potential

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Molecular Biology

Background:

  • Transient receptor potential (TRP) channels are crucial for sensing chemical and thermal stimuli on the ocular surface.
  • Dry eye disease (DED) involves abnormal ocular sensations due to trivial stimuli, with TRP channel dysfunction as a key factor.
  • Specific TRP channels, TRPV1 and TRPM8, are increasingly recognized in DED pathophysiology.

Purpose of the Study:

  • To review the role of TRP channel dysfunction in DED.
  • To discuss therapeutic strategies for DED management.
  • To explore the potential of TRPM8 agonists in treating DED.

Main Methods:

  • Literature review of studies on TRP channels and DED.
  • Analysis of evidence linking TRPV1 and TRPM8 dysfunction to DED.
  • Discussion of TRPM8 agonist mechanisms and applications.

Main Results:

  • TRP channel dysfunction, particularly TRPV1 and TRPM8, is evident in DED.
  • TRPM8 agonists represent a potential therapeutic avenue for DED.
  • Understanding TRP channel roles provides insights into DED mechanisms.

Conclusions:

  • TRP channels play a significant role in DED pathogenesis.
  • TRPM8 agonists offer a promising strategy for managing DED symptoms.
  • Targeting TRP channels may lead to novel DED treatments.