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Updated: Feb 2, 2026

In vitro Uncoating of HIV-1 Cores
Published on: November 8, 2011
IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating
Robert A Dick1, Donna L Mallery2, Volker M Vogt3
1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853-2703, USA. rad82@cornell.edu.
Abstract:
The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood. Recent discoveries of positively-charged rings in the immature and mature protein hexamer subunits that comprise them and their binding to the cellular metabolite inositol hexakisphosphate (IP6) have stimulated exciting new hypotheses. In this paper, we discuss how data from multiple structural and biochemical approaches are revealing potential roles for IP6 in the HIV-1 replication cycle from assembly to uncoating.
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