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Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications

Ahlee Kim1,2, Amy S Shah3,4, Takahisa Nakamura5,6

  • 1Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA. Ahlee.Kim@cchmc.org.

Children (Basel, Switzerland)
|November 18, 2018
PubMed

Insights

Childhood obesity and its metabolic issues are concerning. This review explores how extracellular vesicles (EVs) impact metabolic health and obesity development, offering insights into disease mechanisms.

Area of Science:

  • Metabolic research
  • Cellular biology
  • Public health

Background:

  • Childhood obesity is a significant public health issue with serious metabolic consequences.
  • Metabolic complications include insulin resistance, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), dyslipidemia, and cardiovascular disease.
  • The pathophysiology of these obesity-related complications is not fully understood.

Purpose of the Study:

  • To review current literature on the role of extracellular vesicles (EVs) in metabolic homeostasis.
  • To examine the involvement of EVs in the pathogenesis of obesity and its associated metabolic complications.
  • To discuss future research directions in the field of EVs and metabolic health.

Main Methods:

  • Literature review of studies investigating extracellular vesicles (EVs).
  • Analysis of research on EVs in metabolic regulation and obesity.
  • Synthesis of findings related to EV function in metabolic disease.

Main Results:

  • Extracellular vesicles (EVs) are implicated in intercellular communication relevant to metabolic regulation.
  • Recent studies highlight a critical role for EVs in the pathogenesis of obesity.
  • EVs are involved in the development of metabolic complications associated with obesity.

Conclusions:

  • Extracellular vesicles (EVs) are key players in regulating metabolic homeostasis.
  • Understanding EV function is crucial for unraveling the pathophysiology of obesity and its complications.
  • Further research into EVs offers potential for novel therapeutic strategies for metabolic diseases.

Keywords:
exosomesextracellular vesiclesobesitypediatricstype 2 diabetes

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