Related Experiment Video
Updated: Feb 2, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Management of immunotherapy toxicities in older adults
Shruti Bhandari1, Amitoj S Gill1, Cesar A Perez2
1Division of Hematology and Medical Oncology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.
Abstract:
Advanced age is a risk factor for cancer and is attributed to dysregulation of the immune system. Historically, treatment of advanced cancer has primarily involved systemic chemotherapy that is associated with high treatment related toxicity especially in older adults. Immune checkpoint inhibitors (ICIs) provide an exciting treatment option for older adults in terms of efficacy and safety as compared to systemic chemotherapy. Given the pace of approval of ICIs for multiple cancers, there is an increase in both the use of ICIs and the associated immune-related adverse events. In this article, we address how to approach immunotherapy related toxicities in older adults given the availability of limited data.
Related Concept Videos
Tumor Immunotherapy
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Adult Stem Cells
Tonsillitis II: Management
Impression Management Techniques I: Managing Appearances
Managing Impressions

