Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Review and Preview01:10

Review and Preview

8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

11.3K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.3K
Transcription Factors02:16

Transcription Factors

82.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K
Factors Affecting Solubility04:01

Factors Affecting Solubility

37.1K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.1K
Transcription Elongation Factors02:35

Transcription Elongation Factors

13.9K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
13.9K
Factors Affecting Drug Distribution: Miscellaneous Factors01:19

Factors Affecting Drug Distribution: Miscellaneous Factors

985
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
985

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the determinants of FVIII/FIX levels, bleeding score, and health-related quality of life in the Canadian hemophilia carriers (CHiC) study.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Identifying Educational and Resource Needs of General Internal Medicine Physicians in Sickle Cell Disease Management.

EJHaem·2026
Same author

Iron Deficiency in Women: A Practical Illustrated Review.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

Venous Thromboembolism Prophylaxis and Postoperative Outcomes in Persons with Bleeding Disorders Undergoing Major Surgery: A Canadian Pilot Feasibility Study.

TH open : companion journal to thrombosis and haemostasis·2026
Same author

Optimizing Emergency Department Care for People With Bleeding Disorders: A Scoping Review of Barriers and Interventions for Improvement.

Haemophilia : the official journal of the World Federation of Hemophilia·2026
Same author

Comprehensive care for hereditary angioedema: lessons learned from HAEmophilia Treatment Centers.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2026

Related Experiment Video

Updated: Feb 2, 2026

A Protocol to Acquire the Degenerative Tenocyte from Humans
09:25

A Protocol to Acquire the Degenerative Tenocyte from Humans

Published on: June 9, 2018

7.7K

Acquired factor XIII deficiency: A review.

Matthew Tak Sheng Yan1, Natalia Rydz2, Dawn Goodyear2

  • 1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|November 18, 2018
PubMed
Summary

Acquired factor XIII (FXIII) deficiency is a rare bleeding disorder causing severe hemorrhage. Prompt diagnosis and tailored treatment based on etiology are crucial for managing this condition.

Keywords:
AutoimmuneBleedingCoagulationFactor XIIIHemostasis

More Related Videos

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

12.4K
Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

464

Related Experiment Videos

Last Updated: Feb 2, 2026

A Protocol to Acquire the Degenerative Tenocyte from Humans
09:25

A Protocol to Acquire the Degenerative Tenocyte from Humans

Published on: June 9, 2018

7.7K
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

12.4K
Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

464

Area of Science:

  • Hematology
  • Bleeding Disorders

Background:

  • Acquired factor XIII (FXIII) deficiency is a rare but serious bleeding disorder.
  • It can lead to life-threatening hemorrhages due to immune-mediated inhibition or non-immune FXIII hyperconsumption/hyposynthesis.
  • This deficiency may be idiopathic or linked to comorbidities like malignancies or autoimmune disorders.

Purpose of the Study:

  • To review the clinical characteristics, diagnostic challenges, and therapeutic strategies for acquired FXIII deficiency.
  • To differentiate between immune and non-immune etiologies of acquired FXIII deficiency.
  • To highlight the importance of identifying the underlying cause for effective treatment.

Main Methods:

  • Literature review focusing on acquired FXIII deficiency.
  • Analysis of clinical presentations, diagnostic approaches, and treatment outcomes.
  • Case examples illustrating clinical features.

Main Results:

  • Acquired FXIII deficiency presents with spontaneous or delayed severe bleeding.
  • Diagnosis requires FXIII level testing and potentially inhibitor studies.
  • Treatment varies by cause, including FXIII replacement, antifibrinolytics, or inhibitor eradication.

Conclusions:

  • Early recognition and etiological diagnosis of acquired FXIII deficiency are essential.
  • Treatment strategies must be individualized based on the specific cause of FXIII deficiency.
  • Further research is needed to define treatment targets and thresholds for acquired FXIII deficiency.