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Related Experiment Video

Updated: Feb 2, 2026

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Non-obstructive intracellular nanolasers.

Alasdair H Fikouras¹, Marcel Schubert¹, Markus Karl¹

¹SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, KY16 9SS, Scotland, UK.

Nature Communications

|November 18, 2018

Summary

This summary is machine-generated.

Researchers developed tiny semiconductor nanodisk lasers for biomedical optics. These lasers offer superior spectral definition and low thresholds, enabling advanced cell tracking and study of cell migration and cancer invasion.

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Area of Science:

Biomedical Optics
Nanotechnology
Cell Biology

Background:

Molecular dyes, plasmonic nanoparticles, and colloidal quantum dots are limited by spontaneous emission, causing broad spectral features and low signal-to-noise ratios.
Existing laser integration in cells faces challenges with size and threshold energy.
Advanced optical tools are needed for precise spectral definition and background suppression in cellular imaging.

Purpose of the Study:

To design, fabricate, and integrate semiconductor nanodisk lasers into cells.
To overcome the limitations of size and threshold energy in cellular laser applications.
To enable advanced applications like multiplexed labeling and cell migration studies.

Main Methods:

Utilized GaInP/AlGaInP quantum wells for large optical gain and high refractive index.
Developed high-throughput fabrication methods for semiconductor nanodisk lasers.
Demonstrated intracellular integration and functional testing of the nanolasers.

Main Results:

Achieved laser volumes 1000-fold smaller than the eukaryotic nucleus (<0.1 µm³).
Obtained lasing thresholds 500-fold below typical two-photon microscopy pulse energies (≈0.13 pJ).
Demonstrated excellent spectral stability (<50 pm wavelength shift) and enabled multiplexed cell labeling.

Conclusions:

Semiconductor nanodisk lasers offer unprecedented miniaturization and low thresholds for intracellular applications.
These nanolasers provide a powerful tool for spectral multiplexing and high-resolution cell tracking.
The technology facilitates the study of dynamic cellular processes like migration and cancer invasion.