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Effectiveness of antibiotic therapy in pediatric patients with cat scratch disease

Loujain A Shorbatli1, Katalin I Koranyi2, Milap C Nahata3,4

  • 1College of Pharmacy, The Ohio State University, 500 W. 12th Ave, Columbus, OH, 43210, USA.

International Journal of Clinical Pharmacy
|November 18, 2018
PubMed

Insights

Azithromycin and trimethoprim/sulfamethoxazole (TMP/SMX) show comparable effectiveness in treating pediatric cat scratch disease (CSD). These antibiotics are frequently prescribed, with azithromycin being a suitable option and TMP/SMX a viable alternative.

Area of Science:

  • Infectious Diseases
  • Pediatric Medicine
  • Pharmacology

Background:

  • Cat scratch disease (CSD) treatment in children lacks established antibiotic guidelines.
  • Evaluating antibiotic efficacy is crucial for pediatric CSD management.

Purpose of the Study:

  • To assess antibiotic therapy response rates in pediatric patients diagnosed with CSD.
  • To compare the effectiveness of different antibiotic treatments for CSD in children.

Main Methods:

  • Retrospective review of electronic medical records for pediatric CSD cases (2006-2016).
  • Data included demographics, clinical and lab results, antibiotic regimens, and follow-up outcomes.
  • Analysis focused on treatment response rates for prescribed antibiotics.

Main Results:

  • One hundred seventy-five pediatric patients with confirmed CSD were analyzed.
  • Azithromycin and trimethoprim/sulfamethoxazole (TMP/SMX) were the most common antibiotics used.
  • Resolution or improvement was observed in 51.4% of patients on azithromycin and 61.5% on TMP/SMX, with comparable effectiveness (p=0.56).

Conclusions:

  • Azithromycin and TMP/SMX are frequently prescribed for pediatric CSD.
  • Azithromycin is an appropriate treatment choice for CSD in children.
  • TMP/SMX serves as a potential alternative when azithromycin is not indicated or tolerated.

Keywords:
Antibiotic therapyAzithromycinCat scratch diseasePediatricsTrimethoprim/sulfamethoxazole

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