Related Experiment Video
Updated: Feb 2, 2026
Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
SEOM clinical guidelines for the treatment of non-small cell lung cancer (2018)
1Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025, Barcelona, Spain. mmajem@santpau.cat.
Abstract:
Non-small cell lung cancer (NSCLC) accounts for up to 85% of all lung cancers. The last few years have seen the development of a new staging system, diagnostic procedures such as liquid biopsy, treatments like immunotherapy, as well as deeper molecular knowledge; so, more options can be offered to patients with driver mutations. Groups with specific treatments account for around 25% and demonstrate significant increases in overall survival, and in some subgroups, it is important to evaluate each treatment alternative in accordance with scientific evidence, and even more so with immunotherapy. New treatments similarly mean that we must reconsider what should be done in oligometastatic disease where local treatment attains greater value.
Insights
Recent advancements in non-small cell lung cancer (NSCLC) offer new treatment options for patients with driver mutations. Personalized therapies, including immunotherapy, are improving survival rates and changing the approach to oligometastatic disease.
Area of Science:
- Oncology
- Medical Diagnostics
- Genetics
Background:
- Non-small cell lung cancer (NSCLC) represents a significant majority of lung cancer cases.
- Recent years have introduced novel diagnostic tools like liquid biopsy and advanced molecular profiling for NSCLC.
- The development of targeted therapies and immunotherapies has expanded treatment possibilities for patients with specific driver mutations.
Purpose of the Study:
- To review recent advancements in NSCLC diagnosis and treatment.
- To highlight the impact of molecular knowledge on personalized medicine in NSCLC.
- To discuss the evolving role of immunotherapy and local treatments in oligometastatic NSCLC.
Main Methods:
- Literature review of recent studies on NSCLC staging, diagnostics, and therapeutics.
- Analysis of clinical trial data for targeted therapies and immunotherapies in NSCLC.
- Evaluation of evidence supporting treatment strategies for specific patient subgroups and oligometastatic disease.
Main Results:
- Targeted therapies and immunotherapies show significant improvements in overall survival for specific NSCLC patient groups.
- Liquid biopsy offers a less invasive diagnostic approach for molecular characterization.
- New treatment paradigms are emerging, particularly for patients with driver mutations and in cases of oligometastatic disease.
Conclusions:
- Personalized treatment strategies based on molecular profiling are crucial for optimizing outcomes in NSCLC.
- Immunotherapy and targeted agents represent major progress in NSCLC management.
- The management of oligometastatic NSCLC may increasingly benefit from localized treatment approaches.
Related Concept Videos
02:56Treatment Resistant Cancers
01:11Guidelines for Writing Outcome
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
01:30Guidelines for Nursing Documentation I
Factual:
The following points emphasize the significance of upholding accurate and unbiased documentation in healthcare.
01:23Guidelines for Sketching a Curve
01:26Guidelines for Nursing Documentation II
Timely documentation is crucial to ensure continuity of care for patients. Any delays in recording or reporting medical information can result in medical errors and even adverse patient outcomes. From medication administration to diagnostic test results, every detail must be accurately and promptly documented to provide the best possible care for patients.
01:06Legal Guidelines for Documentation