Related Experiment Video
Updated: Feb 2, 2026
10:25
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
Published on: March 19, 2016
10.0K
Impact of progestogens on hemostasis
Sven O Skouby1, Johannes J Sidelmann2
1Reproductive Medicine Unit, Department of Obstetrics and Gynecology, Herlev/Gentofte Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Phone: +45 38683796, Secretary: +45 38688272.
Hormone Molecular Biology and Clinical Investigation
|November 18, 2018
Summary
Hormonal therapies containing estrogen and progestogen increase venous thrombosis risk. Progestogens primarily affect platelet function and coagulation, influencing hemostasis.
Area of Science:
- Pharmacology
- Hematology
- Endocrinology
Background:
- Combined hormonal contraceptives and postmenopausal hormone therapy are linked to venous thrombosis.
- Thrombotic risk is influenced by estrogen dose and progestogen type.
Purpose of the Study:
- To review the pharmacodynamics of progestogens on the hemostatic system.
- To analyze existing data from animal, cell culture, and clinical studies.
Main Methods:
- Literature review of studies on progestogen effects on hemostasis.
- Analysis of data from in vivo and in vitro experiments.
- Examination of studies involving progestogen-only and combined contraceptives.
Main Results:
- Progestogens significantly alter platelet function and the tissue factor pathway of coagulation.
- Data from combined contraceptives suggest progestogen influence, but extrapolation is challenging.
- Limited clinical data exist for progestogen-only therapy effects on hemostasis.
Conclusions:
- Progestogens exert major effects on hemostasis via platelet and coagulation pathways.
- Further research is needed to clarify progestogen-only therapy impacts on thrombosis risk.
Related Concept Videos
01:24Disorders of Hemostasis
2.2K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.2K
01:05Introduction to Hemostasis
14.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
14.2K
01:19Impact of Groups on Groups
249
Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
249
01:20Extrinsic and Intrinsic Pathways of Hemostasis
12.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
12.7K
01:30Impact
499
Impact occurs when two bodies collide, leading to the application of impulsive forces between them. Analyzing impact mechanics involves considering two colliding particles moving along a line known as the line of impact, which passes through their centers and is perpendicular to the contact plane.
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
499
01:28Impact of Groups on Individuals
352
Groups play a fundamental role in shaping individual behavior, as they establish norms that guide interactions and decision-making. Social psychology examines how individuals conform to group expectations, often adjusting their attitudes and actions to align with group norms. These norms can be formal, such as workplace policies, or informal, such as unspoken social expectations within a fraternity.Conformity and Social InfluenceConformity arises when individuals modify their behaviors or...
352