Predictive factors for adverse outcomes in pediatric patients undergoing low-risk skin and soft tissue surgery: A

Eric C Cheon1, Anthony B Longhini1, Joseph Lee2

  • 1Department of Pediatric Anesthesiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Paediatric Anaesthesia
|November 18, 2018
PubMed

Insights

Pediatric patients with American Society of Anesthesiologists classification ≥3 and nutritional deficiency face higher risks for complications after low-risk skin surgery. Wound or pulmonary issues increase readmission risk.

Area of Science:

  • Pediatric Surgery
  • Surgical Quality Improvement
  • Risk Stratification

Background:

  • Limited data exists on risk stratification for pediatric patients undergoing low-risk skin and soft tissue surgery.
  • Understanding these risks is crucial for optimizing patient care and outcomes.

Purpose of the Study:

  • To determine the incidence of postoperative complications and unplanned 30-day readmissions in children undergoing low-risk skin and soft tissue surgery.
  • To identify independent predictors of these adverse events.

Main Methods:

  • Retrospective analysis of pediatric patients undergoing minor skin and soft tissue procedures.
  • Data collected from American College of Surgeons National Surgical Quality Improvement Program Pediatric hospitals over two years.
  • Primary outcome: 30-day postoperative complication composite; Secondary outcome: unplanned 30-day readmission.

Main Results:

  • A total of 6,730 patients were analyzed, with 2.23% experiencing postoperative complications (primarily wound-related or requiring mechanical ventilation).
  • Independent predictors for complications included American Society of Anesthesiologists classification ≥3 and nutritional deficiency.
  • Unplanned readmissions occurred in 0.61% of patients; wound or pulmonary complications during the index stay predicted readmission.

Conclusions:

  • Pediatric patients with American Society of Anesthesiologists classification ≥3 and nutritional deficiency are at increased risk for complications after low-risk surgery.
  • Postoperative wound or pulmonary complications elevate the risk of 30-day readmission.
  • Identifying high-risk patients allows for targeted interventions to minimize complications.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
262
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
304
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
226
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
296
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
325