Related Experiment Video
Updated: Feb 2, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
Published on: June 18, 2018
The inverse relationship between life expectancy-induced changes in the old-age dependency ratio and the prospective
Dalkhat M Ediev1, Warren C Sanderson2, Sergei Scherbov3
1Wittgenstein Centre for Demography and Global Human Capital (IIASA, VID/ÖAW, WU), International Institute for Applied Systems Analysis, Schlossplatz 1, 2361 Laxenburg, Austria; North-Caucasian State Humanitarian-Technological Academy, Institute for Applied Mathematics and Information Technologies, Stavropolskaya 36, Cherkessk, 369000, Russian Federation.
Abstract:
Unlike other biological populations, the human population is experiencing long-run increases in life expectancy. Those lead to changes in age compositions not typical for other biological populations. Sanderson and Scherbov (2015a) demonstrated that, in many countries in Europe, faster increases in life expectancy lead to faster population aging when measured using the old-age dependency ratio and to slower population aging when measured using the prospective old-age dependency ratio that employs a dynamic old-age threshold. We examine this finding analytically and with simulations. We use an analytic decomposition of changes in mortality schedules into shift and compression processes. We show that shifts and compressions of mortality schedules push the two old-age dependency ratios in opposite directions. Our formal results are supported by simulations that show a positive effect of a mortality shift on the old-age dependency ratio and a negative effect of it on the prospective old-age dependency ratio. The effects are of opposite sign for a mortality compression. Our formal and simulation results generalize observed European trends and suggest that the inverse relationship between life expectancy and prospective old-age dependency would be observed more generally.
Related Concept Videos
Poisson's Ratio
Odds Ratio
Hazard Ratio
For example, in a clinical trial...
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Frequency-dependent Selection

