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Updated: Feb 2, 2026

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
Neonatal Hypoglycemia: Is There a Sweet Spot?
Mary L Puchalski1, Terri L Russell1, Kristine A Karlsen2
1Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Neonatology, 25 East Chicago Avenue, Chicago, IL 60611, USA; Department of Women, Children, and Family Health Science, University of Illinois at Chicago, 845 South Damen Avenue, M/C 802, Chicago, IL 60612, USA.
Abstract:
Hypoglycemia is one of the most common neonatal problems. Despite increasing evidence that hypoglycemia is linked to neurologic impairment, knowledge regarding the specific value or duration of hypoglycemia that results in injury to the brain remains unclear. Current published statements/guidelines focused on preventing clinically significant hypoglycemia are conflicting and continue to be based on low evidence. This article reviews transitional events leading to extrauterine euglycemia, risk factors contributing to transient or persistent hypoglycemia, and common treatment approaches. Current information related to neurodevelopmental outcomes and screening strategies to prevent significant hypoglycemia with early treatment is described.
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