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Related Experiment Video

Updated: Feb 2, 2026

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Glucocorticoids and resilience.

Joanna L Spencer-Segal1, Huda Akil2

  • 1Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, United States of America; Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States of America.

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Summary
This summary is machine-generated.

Organisms adapt to stress through resilience, a process involving neural pathways and glucocorticoid signaling. Understanding this neurobiology can help promote positive adaptation during stressful events.

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Area of Science:

  • Neurobiology
  • Stress Physiology
  • Behavioral Adaptation

Background:

  • Organisms face constant challenges to homeostasis requiring adaptation.
  • Stress adaptation can result in behavioral susceptibility or resilience.
  • The neurobiology of stress resilience is less studied than stress-induced damage.

Purpose of the Study:

  • To highlight the under-appreciated role of resilience as a stress adaptation.
  • To propose that neural pathways for resilience are initiated during stress.
  • To emphasize the involvement of glucocorticoid signaling in resilience.

Main Methods:

  • This study is a conceptual review and synthesis of existing research.
  • It focuses on the neurobiological mechanisms underlying stress resilience.
  • It discusses the identification of individuals vulnerable to stress.

Main Results:

  • Resilience pathways are initiated at the time of stress.
  • Glucocorticoid signaling plays a crucial role in initiating resilience.
  • Focusing on resilience induction can identify vulnerable individuals.

Conclusions:

  • Resilience is a key adaptive response to stress.
  • Neural pathways and glucocorticoid signaling are critical for resilience.
  • Interventions targeting resilience at the time of stress may promote positive adaptation.