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Related Experiment Videos

Pseudoacromegaly.

Pedro Marques1, Márta Korbonits1

  • 1Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

Frontiers in Neuroendocrinology
|November 19, 2018
PubMed
Summary
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Pseudoacromegaly presents with physical features similar to acromegaly or gigantism but lacks growth hormone (GH) axis abnormalities. This review aids physicians in diagnosing rare pseudoacromegaly conditions, distinguishing them from true GH excess disorders.

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Genetics

Background:

  • Acromegaloid appearance or tall stature often prompts evaluation for growth hormone (GH) excess.
  • While some cases are normal variants, others present as acromegaly or pituitary gigantism, typically diagnosed via GH/IGF-1 axis assessment.
  • A subset of patients exhibits acromegaly-like or gigantism-like features without GH axis abnormalities, a condition termed pseudoacromegaly.

Purpose of the Study:

  • To provide a comprehensive overview of pseudoacromegaly conditions.
  • To highlight similarities and differences between pseudoacromegaly, acromegaly, and pituitary gigantism.
  • To assist physicians in diagnosing patients presenting with pseudoacromegaly.

Main Methods:

  • Literature review of pseudoacromegaly, acromegaly, and pituitary gigantism.
Keywords:
AcromegaloidismAcromegalyGigantismOvergrowthPseudoacromegalyTall stature

Related Experiment Videos

  • Comparative analysis of clinical features and diagnostic criteria.
  • Emphasis on differentiating conditions based on GH/IGF-1 axis evaluation.

    • Main Results:

    • Pseudoacromegaly is characterized by physical features mimicking GH excess disorders but with a normal GH/IGF-1 axis.
    • Diagnosis can be challenging due to rarity, variability, and overlapping characteristics.
    • Distinguishing pseudoacromegaly from true acromegaly/gigantism is crucial for appropriate management.

    Conclusions:

    • Pseudoacromegaly represents a diagnostic challenge requiring careful evaluation beyond standard GH axis testing.
    • Understanding the nuances of pseudoacromegaly is essential for accurate diagnosis and patient care.
    • This review serves as a guide for clinicians encountering patients with features suggestive of GH excess but lacking biochemical evidence.