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A double-blind clinical comparison of two dosage schedules of cefatrizine in children

P Careddu1, G Ceccarelli

  • 1First Institute of Paediatric Clinics, Milan University, Italy.

The Journal of International Medical Research
|May 1, 1988
PubMed

Insights

Once daily administration of cefatrizine is as effective as twice daily dosing for treating bacterial respiratory tract infections in children. This simplifies treatment for pediatric outpatients with good clinical outcomes.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Clinical Microbiology

Background:

  • Bacterial infections of the respiratory tract are common in children.
  • Optimizing antibiotic dosing regimens can improve adherence and efficacy.

Purpose of the Study:

  • To compare the effectiveness of once-daily versus twice-daily cefatrizine in pediatric outpatients.
  • To evaluate clinical outcomes and bacterial eradication rates.

Main Methods:

  • Double-blind, randomized clinical trial involving 30 pediatric outpatients.
  • Cefatrizine administered at 75 mg/kg/day for 8 days, either once or twice daily.
  • Evaluation of fever, clinical symptoms, bacterial eradication, and tolerance.

Main Results:

  • No significant differences in effectiveness between once-daily and twice-daily cefatrizine administration.
  • Similar rates of fever resolution, symptom improvement, and bacterial eradication.
  • Overall tolerance was comparable between the two dosing groups.

Conclusions:

  • Once-daily cefatrizine is a viable and effective treatment option for pediatric respiratory tract infections.
  • Simplified dosing may enhance treatment adherence in pediatric outpatients.
  • Results align with previous adult studies, supporting once-daily administration.

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