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Encapsulating S-nitrosogluthatione (GSNO) into nanoparticles offers a sustained nitric oxide (NO•) release, suggesting potential for oral therapies like inflammatory bowel disease treatments.

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Area of Science:

  • Biomedical Science
  • Nanotechnology
  • Pharmacology

Background:

  • S-nitrosogluthatione (GSNO) is a nitric oxide (NO•) donor with a short half-life, limiting its therapeutic use.
  • Nanoparticle encapsulation can protect GSNO and enable sustained NO• release.

Purpose of the Study:

  • To investigate the transcriptomic effects of free and nano-encapsulated GSNO on THP-1 human monocytes.
  • To assess the potential of Eudragit® nanoparticles for controlled GSNO delivery.

Main Methods:

  • RNA microarray analysis of THP-1 cells exposed to free or Eudragit® nano-encapsulated GSNO at 4h and 24h.
  • Two doses (1.4 and 6 µM) of GSNO were tested.

Main Results:

  • Free GSNO exposure altered genes in apoptosis, differentiation, immune response, and metabolism.
  • Both free and encapsulated GSNO activated genes related to blood coagulation, immune response, and cell cycle.
  • Nano-encapsulated GSNO demonstrated a progressive release profile.

Conclusions:

  • Eudragit® nano-encapsulation of GSNO facilitates sustained release, indicating potential for oral therapeutic applications.
  • This approach may be beneficial for treating conditions like inflammatory bowel diseases.