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Updated: Feb 2, 2026
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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
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Incretin-based therapy for diabetic ulcers: from bench to bedside
Hui-Chun Ku1, Yao-Jen Liang1,2
1a Department and Institute of Life Science , Fu-Jen Catholic University , New Taipei City , Taiwan.
Expert Opinion on Investigational Drugs
|November 20, 2018
Summary
Incretin-based therapy shows promise for treating diabetic foot ulcers by reducing inflammation and improving tissue healing. Further clinical trials are needed to confirm the benefits of these treatments for diabetes complications.
Area of Science:
- Endocrinology and Metabolism
- Wound Healing Research
- Pharmacology
Background:
- Diabetic foot ulcers (DFUs) are a severe diabetes complication, causing pain, disability, and reduced quality of life.
- Incretin-based therapies are established treatments for type-2 diabetes, offering benefits beyond glycemic control.
Purpose of the Study:
- To review preclinical and clinical evidence for incretin-based treatments in managing DFUs.
- To explore the potential of incretin mimetics in improving DFU outcomes.
Main Methods:
- Systematic review of existing literature.
- Analysis of preclinical studies and clinical trial data on incretin-based therapies for DFUs.
Main Results:
- Incretin-based therapy demonstrates potential benefits including anti-inflammatory effects, enhanced keratinocyte migration, angiogenesis induction, and improved tissue remodeling.
- Evidence suggests these mechanisms may contribute to improved healing of diabetic ulcers.
Conclusions:
- Incretin-based therapies may offer a novel treatment strategy for diabetic foot ulcers.
- Large-scale clinical trials are essential to validate the efficacy of GLP-1 receptor agonists and DPP4 inhibitors for DFUs.
- Future research should investigate topical applications of incretin-based treatments for enhanced wound healing.
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