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Related Concept Videos

Self-Presentation01:25

Self-Presentation

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Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
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Self-Presentation: Self-Monitoring and Self-Handicapping02:05

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People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
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Strategies of Self-Presentation I: Strategic Self-Presentation01:12

Strategies of Self-Presentation I: Strategic Self-Presentation

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Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
219
Processes of Self-Presentation01:29

Processes of Self-Presentation

249
Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
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Strategies of Self-Presentation II: Self-Verification01:17

Strategies of Self-Presentation II: Self-Verification

192
Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
192
Strategies of Self-Presentation III: Self-Monitoring01:24

Strategies of Self-Presentation III: Self-Monitoring

262
Self-monitoring is a central construct in understanding individual differences in self-presentation strategies across social contexts. It refers to how individuals observe, regulate, and control their expressive behavior and self-presentation following situational cues. Self-monitoring reflects a person's sensitivity to social appropriateness and willingness to adapt behavior to fit varying interpersonal demands.High vs. Low Self-Monitoring IndividualsIndividuals high in self-monitoring are...
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Related Experiment Video

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Olfactory Context Dependent Memory: Direct Presentation of Odorants
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MR1-dependent antigen presentation.

Elham Karamooz1, Melanie J Harriff2, David M Lewinsohn3

  • 1Pulmonary & Critical Care Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

Seminars in Cell & Developmental Biology
|November 20, 2018
PubMed
Summary

Mucosal Associated Invariant Natural Killer T (MAIT) cell receptor 1 (MR1) presents microbial metabolites, acting as a sensor for intracellular infections. This review details MR1-dependent antigen presentation, highlighting its role in detecting the microbial metabolome.

Keywords:
Antigen presentationMR1Mucosal associated invariant T cells

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Area of Science:

  • Immunology
  • Molecular Biology
  • Microbiology

Background:

  • MR1 (Mucosal Associated Invariant Natural Killer T cell receptor 1) is a non-classical MHC class I molecule conserved in mammals.
  • MR1's ligands and antigens for MR1-restricted T cells have only recently been identified.
  • MR1 is primarily located intracellularly, unlike classical MHC class I molecules.

Purpose of the Study:

  • To review the current understanding of MR1-dependent antigen presentation.
  • To highlight MR1's role as a sensor of the microbial metabolome.
  • To discuss MR1's potential in early detection of intracellular infections.

Main Methods:

  • Review of existing literature on MR1 structure, function, and antigen presentation.
  • Analysis of MR1's intracellular localization and ligand-binding properties.
  • Discussion of MR1's role in T cell recognition of microbial metabolites.

Main Results:

  • MR1 presents non-peptidic small molecules, particularly those from the riboflavin biosynthesis pathway.
  • Mammals do not synthesize riboflavin, making MR1 a specific sensor of microbial metabolites.
  • MR1's intracellular localization facilitates its role in detecting intracellular microbial activity.

Conclusions:

  • MR1 functions as a crucial link between microbial metabolism and the host immune system.
  • MR1-restricted T cells can detect intracellular infections through MR1's sensing of microbial metabolites.
  • Further research into MR1-dependent antigen presentation is vital for understanding host-microbe interactions and developing new diagnostics.