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Related Experiment Videos

Paget's disease of bone.

Natasha M Appelman-Dijkstra1, Socrates E Papapoulos1

  • 1Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands.

Best Practice & Research. Clinical Endocrinology & Metabolism
|November 20, 2018
PubMed
Summary

Paget

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Area of Science:

  • Bone Biology and Skeletal Disorders
  • Rheumatology and Endocrinology

Background:

  • Paget's disease of bone is a common, focal skeletal disorder characterized by abnormal bone remodeling.
  • It can lead to significant bone deformities and complications, including skeletal, articular, and vascular issues.
  • While its prevalence may be decreasing, understanding its pathogenesis is crucial.

Purpose of the Study:

  • To elucidate the underlying mechanisms of Paget's disease of bone.
  • To provide a comprehensive overview of the current understanding of this bone disorder.

Main Methods:

  • Review of existing literature on Paget's disease of bone.
  • Analysis of epidemiological data and clinical observations.

Main Results:

  • Paget's disease of bone is a slowly progressive condition affecting bone shape and size.
  • It is the second most common bone disorder globally, following osteoporosis.
  • Despite effective diagnosis and treatment, the exact pathogenesis remains unclear.

Conclusions:

  • Paget's disease of bone requires further research into its pathogenesis.
  • Continued investigation is necessary for improved therapeutic strategies.
  • Understanding the disease is key to managing its complications.
Keywords:
Paget's diseaseSQSTM1bone turnovergeneticszoledronate

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