Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Structure01:55

Bone Structure

51.7K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.7K
Bone Remodeling01:40

Bone Remodeling

40.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.4K
Compact Bone01:27

Compact Bone

16.5K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.5K
Bone Disorders01:29

Bone Disorders

5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K
The Hyoid Bone01:12

The Hyoid Bone

5.0K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.0K
Spongy Bone01:09

Spongy Bone

7.9K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons.

Cell biochemistry and function·2026
Same author

The Paraoxonase (<i>PON</i>) Gene Family in Health, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Other Diseases.

International journal of molecular sciences·2025
Same author

The preclinical discovery and development of romosozumab for the treatment of people with severe osteoporosis who are at high risk of fracture.

Expert opinion on drug discovery·2025
Same author

Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration.

Clinical epigenetics·2025
Same author

Loss of the Ubiquitin-Associated Domain of sqstm1/p62 in Zebrafish Causes a Phenotype Resembling Paget's Disease of Bone.

Calcified tissue international·2025
Same author

A Case-Control Study Supports Genetic Contribution of the <i>PON</i> Gene Family in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease.

Antioxidants (Basel, Switzerland)·2024
Same journal

Control of muscle mass and accretion.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Multiple endocrine neoplasia type 2: From molecular genetics to precision therapy.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Nutritional advice for patients with obesity and prediabetes.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Effects of prolonged physical training on skeletal muscle mass accrual throughout the life span.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Type 2 diabetes and obesity in South Asian patients with polyendocrine metabolic ovarian syndrome: The emerging role of metabolomics.

Best practice & research. Clinical endocrinology & metabolism·2026
Same journal

Stress and the interaction of the hypothalamic-pituitary-adrenal axis with other pituitary axes and its consequences on muscle mass.

Best practice & research. Clinical endocrinology & metabolism·2026
See all related articles

Related Experiment Video

Updated: Feb 2, 2026

Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs
08:40

Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs

Published on: April 19, 2024

3.7K

Sclerosing bone dysplasias.

Eveline Boudin1, Wim Van Hul1

  • 1Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

Best Practice & Research. Clinical Endocrinology & Metabolism
|November 20, 2018
PubMed
Summary
This summary is machine-generated.

Sclerosing bone dysplasias are rare genetic disorders classified into three subgroups. This overview details their symptoms, genetic causes, and treatments for better understanding and management.

Keywords:
bone densitydifferential diagnosishyperostosisosteopetrosissclerosing bone disorders

More Related Videos

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.3K

Related Experiment Videos

Last Updated: Feb 2, 2026

Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs
08:40

Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs

Published on: April 19, 2024

3.7K
Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.3K

Area of Science:

  • Medical Genetics
  • Skeletal Dysplasias
  • Radiology

Background:

  • Sclerosing bone dysplasias represent a rare, heterogeneous group of genetic skeletal disorders.
  • The 2015 Nosology and classification of genetic skeletal disorders categorizes them into three main subgroups.

Purpose of the Study:

  • To provide a comprehensive overview of sclerosing bone dysplasias.
  • To summarize key radiographic and clinical features, genetic underpinnings, and therapeutic strategies for these rare conditions.

Main Methods:

  • Review of current literature and classification systems.
  • Synthesis of information on radiographic and clinical manifestations.
  • Summary of genetic defects and treatment options.

Main Results:

  • The study outlines three primary subgroups: neonatal osteosclerotic dysplasias, osteopetroses and related disorders, and other sclerosing bone disorders.
  • Key diagnostic criteria, genetic mutations, and emerging treatments are presented for each subgroup.

Conclusions:

  • Understanding the heterogeneity of sclerosing bone dysplasias is crucial for accurate diagnosis and management.
  • This overview serves as a valuable resource for clinicians and researchers in the field of genetic skeletal disorders.