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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
Asthma, rhinitis, and nasal polyp multimorbidities
José Antonio Castillo Vizuete1, Joaquín Sastre2, Alfonso Del Cuvillo Bernal3
1Servicio de Neumología, Hospital Universitario Quirón Dexeus, Barcelona. Coordinador Grupo de Rinitis, Área de Asma SEPAR, Barcelona, España.
This review highlights the connection between upper and lower airway diseases, particularly asthma. Evaluating sinonasal conditions alongside asthma is crucial for comprehensive patient management and treatment.
Area of Science:
- Respiratory Medicine
- Otolaryngology
- Immunology
Background:
- Asthma often coexists with upper airway diseases.
- A shared inflammatory pathway links sinonasal conditions and asthma.
- Understanding these interrelationships is key for effective management.
Purpose of the Study:
- To provide pulmonologists with guidance on managing upper and lower airway diseases.
- To define sinonasal phenotypes associated with asthma.
- To emphasize the concept of the "united airway" in clinical practice.
Main Methods:
- Review of existing literature on asthma and sinonasal diseases.
- Discussion of epidemiological links, clinical presentations, and inflammatory mechanisms.
- Categorization of sinonasal phenotypes, including allergic rhinitis and chronic rhinosinusitis.
Main Results:
- Identified key sinonasal phenotypes linked to asthma: allergic rhinitis and chronic rhinosinusitis with or without nasal polyps.
- Highlighted allergic rhinitis as the most common comorbidity.
- Emphasized chronic rhinosinusitis with nasal polyps as strongly associated with severe asthma.
Conclusions:
- Integrated management of upper and lower respiratory tracts is essential for optimal asthma control.
- Systematic evaluation of the upper airway is necessary for a unified diagnosis and treatment plan.
- The "united airway" concept guides comprehensive care for patients with comorbid conditions.
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Clinical Assessment for Asthma:
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Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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