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Related Experiment Video

Updated: Feb 2, 2026

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

Published on: January 20, 2017

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Sarcoidosis.

S Salah1, S Abad2, D Monnet1

  • 1Department of Ophthalmology, hôpital Cochin, Assistance publique-Hôpitaux de Paris, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.

Journal Francais D'Ophtalmologie
|November 20, 2018
PubMed
Summary
This summary is machine-generated.

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Ocular sarcoidosis, an inflammatory eye condition, often presents as uveitis. Diagnosis can be challenging without systemic evidence, but treatment typically involves steroids or immunosuppressants.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Sarcoidosis is a systemic granulomatosis affecting multiple organs, commonly the lungs, skin, and eyes.
  • Ophthalmological involvement occurs in 20-50% of sarcoidosis cases, often manifesting as granulomatous uveitis.
  • Diagnosing ocular sarcoidosis can be difficult, especially when systemic involvement is not apparent.

Purpose of the Study:

  • To review the diagnostic challenges and treatment strategies for ocular sarcoidosis.
  • To highlight the typical clinical presentation of ocular sarcoidosis.
  • To discuss current therapeutic options for managing ocular sarcoidosis.

Main Methods:

  • Review of clinical, paraclinical, and histological findings in sarcoidosis diagnosis.
Keywords:
Epithelioid and giant cell granulomaGranulomatous uveitisHeerfordt syndromeMikulicz syndromeMultifocal choroiditisPosterior uveitisSystemic granulomatosis

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Last Updated: Feb 2, 2026

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
11:02

Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry

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  • Analysis of ophthalmological signs suggestive of ocular sarcoidosis.
  • Evaluation of treatment responses to corticosteroids and immunosuppressants.

    • Main Results:

    • Ocular sarcoidosis diagnosis often relies on clinical and histological evidence, sometimes requiring algorithms for isolated uveitis.
    • Steroid-responsive uveitis is common, but corticosteroid-dependent cases necessitate further immunosuppression.
    • Anti-tumor necrosis factor alpha agents offer an alternative for refractory ocular sarcoidosis.

    Conclusions:

    • Ocular sarcoidosis diagnosis requires a comprehensive approach, integrating systemic and ocular findings.
    • Effective management of ocular sarcoidosis involves a stepwise therapeutic strategy, starting with steroids and progressing to immunosuppressants or biologics.
    • Further research may elucidate the mechanisms behind isolated ocular sarcoidosis to improve diagnostic accuracy.