Implementing a minimally invasive approach (combining radial approach, small guiding catheters and minimization of double access) for coronary chronic total occlusion intervention according to the hybrid algorithm: The Minimalistic Hybrid Algorithm
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Updated: Feb 2, 2026

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
Carlo Zivelonghi1, Jan P van Kuijk1, Maarten J Suttorp1
1Department of Cardiology, Sint Antonius Ziekenhuis, the Netherlands.
Insights
A new "Minimalistic Hybrid Algorithm" streamlines percutaneous recanalization of coronary chronic total occlusions (CTOs). This approach reduces the need for dual access and large catheters, potentially lowering patient discomfort and complications.
Area of Science:
- Interventional Cardiology
- Vascular Surgery
Background:
- Percutaneous recanalization of coronary chronic total occlusions (CTOs) typically involves dual access and large bore catheters, often via a transfemoral approach.
- This conventional method can lead to increased patient discomfort and procedural risks.
Purpose of the Study:
- To introduce and describe the
- Minimalistic Hybrid Algorithm
- , an alternative strategy for CTO recanalization.
- To minimize the use of dual access, large bore catheters, and transfemoral approaches.
- To reduce patient discomfort and potential procedural complications.
Main Methods:
- The algorithm categorizes CTO lesions as "simple" or "complex" based on scoring systems and operator expertise.
- It integrates antegrade and retrograde approaches, along with subintimal and intraluminal techniques.
- The strategy prioritizes single-catheter, transradial access for simpler cases, reserving more invasive methods for complex ones.
Main Results:
- The described algorithm offers a novel sequence for procedural strategy in CTO recanalization.
- It aims to limit invasiveness by optimizing the choice of access and catheter size.
- Potential benefits include reduced patient discomfort and fewer procedural complications.
Conclusions:
- The "Minimalistic Hybrid Algorithm" presents a viable alternative for CTO recanalization.
- It has the potential to decrease reliance on dual access, large bore catheters, and femoral approaches.
- This approach represents an evolution of the classic "Hybrid Algorithm" for CTO treatment.
Abstract:
Percutaneous recanalization of coronary chronic total occlusions (CTOs) traditionally relies on the use of dual access and large bore catheters, with trans-femoral approach adoption in most of the cases. Aim of this manuscript is to describe an alternative algorithm, that we called "Minimalistic Hybrid Algorithm", in order to minimize the use of double access, large bore catheters, and femoral approach thus reducing patient's discomfort and possibly procedural complications. This algorithm can be interpreted as an evolution of the classic "Hybrid Algorithm" and requires the operator to be confident with all techniques known in this conventional algorithm. Indeed, all possible techniques and approaches of the conventional hybrid approach to treat CTOs are included in a novel diagram for procedural strategy, which offers an alternative sequence of steps to limit, whenever possible, the invasiveness of the procedure. After dividing the cases in "simple" or "complex" CTO lesions according to the available complexity scores and to the "feeling", knowledge and expertise of the operator, a systematic description of the procedural steps is provided. This includes antegrade and retrograde approaches, as well as sub-intimal and intra-luminal techniques, in order to maintain the simpler single-catheter transradial strategies in the first line for the simple CTO, and the adoption of more complex, double access and transfemoral ones in the further steps. The minimalistic hybrid algorithm herein described is a possible alternative sequence of steps in the setting of CTO recanalization, with the potential of limiting the use of double access, large bore catheters, and femoral approach.
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