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Treating chancroid with enoxacin.

W Naamara¹, D Y Kunimoto, L J D'Costa

¹Centre for Microbiology Research, Kenya Medical Research Institute.

Genitourinary Medicine

|June 1, 1988

Summary

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Enoxacin and trimethoprim/sulphametrole (TMP/SMT) showed similar efficacy in treating chancroid, a bacterial infection. Further research is needed to determine the optimal antimicrobial regimen for Haemophilus ducreyi infections.

Area of Science:

Microbiology
Infectious Diseases
Clinical Pharmacology

Background:

Antimicrobial resistance in Haemophilus ducreyi necessitates evaluating new treatment options for chancroid.
Enoxacin demonstrates potent in vitro activity against H. ducreyi.

Purpose of the Study:

To compare the efficacy of enoxacin with trimethoprim/sulphametrole (TMP/SMT) for treating chancroid.
To assess the eradication rates of H. ducreyi following treatment with enoxacin or TMP/SMT.

Main Methods:

A randomized clinical trial involving 169 men with chancroid.
Comparison of three doses of enoxacin (400 mg) against a single dose of TMP/SMT (640/3200 mg).
Clinical assessment of ulcer improvement/cure and microbiological eradication of H. ducreyi.

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Main Results:

Ulcer improvement or cure rates were similar between enoxacin (65/73) and TMP/SMT (57/70) groups (p > 0.05).
H. ducreyi eradication at 72 hours was comparable: 72/77 for enoxacin and 67/74 for TMP/SMT.
Both treatments were effective for patients with buboes, and all tested H. ducreyi strains were susceptible to both agents in vitro.

Conclusions:

Neither enoxacin nor TMP/SMT emerged as the optimal treatment for chancroid in this study.
Enoxacin exhibits efficacy for soft tissue infections caused by Gram-negative organisms like H. ducreyi.