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[Diagnosis and Treatment of MSI-H Cancer in the Urological Malignancy]
Takashi Kawahara1, Hiroyuki Nishiyama
1Dept. of Urology, Faculty of Medicine, University of Tsukuba.
Abstract:
In May 2017, the Food and DrugAdministration granted accelerated approval to pembrolizumab for microsatellite instability- high(MSI-H)or deficient mismatch repair(dMMR)solid tumors irrespective to tumor origins. Lynch syndrome is one of the diseases causingMSI -H tumor, however some sporadic cancers have MSI-H. We focus on the frequency of Lynch syndrome and sporadic MSI-H tumor in urological cancer.
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