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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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PLGA-Based Nanoparticles in Cancer Treatment
Sima Rezvantalab1,2, Natascha Ingrid Drude2,3, Mostafa Keshavarz Moraveji1
1Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Frontiers in Pharmacology
|November 20, 2018
Summary
Poly (lactic-co-glycolic acid) (PLGA) nanoparticles offer versatile cancer therapies, including targeted drug delivery. This review highlights PLGA
Area of Science:
- Biomaterials Science
- Nanotechnology
- Oncology
Background:
- Nanomedicines are crucial for advanced cancer treatments like targeted drug delivery, hyperthermia, and photodynamic therapy.
- Poly (lactic-co-glycolic acid) (PLGA) based materials are extensively utilized in nanomedicine formulations for cancer therapy.
Purpose of the Study:
- To provide a comprehensive overview of Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs).
- To discuss the properties, biological behavior, and applications of PLGA NPs in cancer therapy.
- To emphasize strategies for passive and active targeting of PLGA NPs to tumors and explore combination therapies.
Main Methods:
- Review of existing literature on PLGA nanoparticles for cancer therapy.
- Analysis of properties, biological interactions, and targeting strategies for PLGA NPs.
- Evaluation of combination therapies to enhance NP accumulation and therapeutic efficacy.
Main Results:
- PLGA nanoparticles exhibit diverse properties suitable for various cancer treatment modalities.
- Passive and active targeting strategies effectively direct PLGA NPs to tumor sites.
- Combination therapies significantly improve NP accumulation and therapeutic outcomes.
Conclusions:
- PLGA nanoparticles demonstrate significant potential as drug delivery systems for cancer therapeutics.
- Extensive research highlights the promise of PLGA NPs, encouraging further translational studies.
- Targeted delivery and combination strategies enhance the efficacy of PLGA-based nanomedicines.
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